Fucosylated protein of retinal cone photoreceptor outer segments: morphological and biochemical analyses
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چکیده
منابع مشابه
Fucosylated protein of retinal cone photoreceptor outer segments: morphological and biochemical analyses
Cone outer segments (OS) of the goldfish retina are diffusely labeled after intravitreal injection of [(3)H]fucose while rod OS remain unlabeled. By electron microscopic radioautography, the OS of red- and blue-sensitive cones are heavily labeled while green- sensitive cone OS are lightly labeled. The time-course and pattern of OS labeling in all cone types from 30 min to 24 h resemble that of ...
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Lecithin retinol acyl transferase (LRAT) and retinal pigment epithelium protein 65 (RPE65) are key enzymes of the retinoid cycle. In Lrat(-/-) and Rpe65(-/-) mice, models of human Leber congenital amaurosis, the retinoid cycle is disrupted and 11-cis-retinal, the chromophore of visual pigments, is not produced. The Lrat(-/-) and Rpe65(-/-) retina phenotype presents with rapid sectorial cone deg...
متن کاملA concentration of fucosylated glycoconjugates at the base of cone outer segments: quantitative electron microscope autoradiography.
Rod photoreceptors show a discrete band of labeled molecules at the outer segment base shortly after the administration of radioactive protein precursors (Young, 1967). The band signifies the insertion of radiolabeled protein, primarily opsin, into rod disc membrane (Basinger, Bok and Hall, 1976). In contrast, the autoradiographic labeling pattern in cones is characteristically diffuse (Young, ...
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Photoreceptors are damaged in many common eye diseases, such as macular degeneration, retinal detachment, and retinitis pigmentosa. The development of methods to promote the repair or replacement of affected photoreceptors is a major goal of vision research. In this context, it would be useful to know whether photoreceptors are capable of undergoing some degree of spontaneous regeneration after...
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The utilization of methionine-(3)H by retinal photoreceptor cells has been studied by radioautographic technique in the rat, mouse, and frog. In all three species, the labeled amino acid is concentrated initially in the inner segment of the cell. Within 24 hr, the radioactive material is displaced to the base of the outer segment, where it accumulates as a distinct reaction band. The reaction b...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1982
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.92.2.269